When asked about the best medicine for acid reflux, we can only respond by saying that the goal is to use the least powerful drug taken as infrequently as possible to control these symptoms in a satisfactory way. PPIs, in particular, carry significant long-term side effects, so it is desirable to get off of them, if. This partially digested material is usually acidic and can irritate the esophagus, often causing heartburn and other symptoms. See also: sub-topics. Drugs Used to Treat GERD. The following list of medications are in some way related to, or used in the treatment of this condition.
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